Sunday Times 2
Lab-engineered jellyfish may mend a broken heart
View(s):(AFP) Using cells from rat hearts and a seer polymer film, scientists reported they had created an artificial jellyfish that could one day help save patients with heart disease.
The exploit marks an advance in so-called biomimicry, in which a natural wonder inspires copycat innovation in the lab.
The interest in the jellyfish lies in its remarkable swimming ability, which comes from muscles that open its bell-like body and then contract it, thus ejecting water and driving the creature along. This pump-like design has been honed by more than 500 million years of evolution to be as simple and energy-efficient as possible. As a result, it offers tempting insights for scientists hoping to make small, reliable heart pumps for the future.
“It occurred to me in 2007 that we might have failed to understand the fundamental laws of muscular pumps,” said Kevin Kit Parker, a professor of bio-engineering at the Harvard School of Engineering and Applied Sciences. “I started looking at marine organisms that pump to survive. Then I saw a jellyfish at the New England Aquarium, and I immediately noted both similarities and differences between how the jellyfish and the human heart pump.”
The paper is published on Sunday in the journal Nature Biotechnology.Dubbed “Medusoid” after the Medusa, the snake-haired creature of mythology that provides the Latin name for jellyfish, the lab creature has a body of an ultra-thin silicone polymer with eight limb-like appendages.
The arms are coated with a protein in patterns that resemble the muscle architecture of the real jellyfish.
The protein’s job is to act as a nutritional scaffold to grow and direct a batch of cells derived from the muscles of rat hearts.
Thus primed for action, Medusoid was unleashed in a lab container of electrically conductive fluid. The scientists threw a switch to put a tiny voltage, ranging from one to five volts, into the fluid to make Medusoid’s muscle cells contract and relax rhythmically.
“I was surprised that with relatively few components — a silicone base and cells that we arranged — we were able to reproduce some pretty complex swimming and feeding behaviours that you see in biological jellyfish,” said John Dabiri, a professor of aeronautics and bio-engineering at the California Institute of Technology (Caltech).
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