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Reducing menopausal difficulties
Is hormone replacement therapy a solution for women suffering from severe cases of menopause? Esther Williams finds out

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'To take estrogen or not to take estrogen.' The subject has stimulated so much debate that women approaching menopause are unsure of what action to take in view of the contradictory information available. While some studies show that this potent hormone can ward off many age-related ailments, it also suggests the increase in chances of getting breast cancer.

When women reach the age of 45 - 50, their ovaries gradually produce lower levels of estrogen before stopping altogether. It is the last stage of a biological process, a transition between a woman's childbearing years and her non-childbearing years called menopause. Women who have had surgery to remove both their ovaries experience surgical menopause, when hormone production and menstruation stop immediately.

Estrogen and other female sex hormones such as progesterone and testosterone are involved in the development and maintenance of secondary sex characteristics such as breasts and affect many aspects of women's physical and emotional health.

According to Prof. Harsha Seneviratne, "Estrogen is a hormone that makes women what they are. Manufactured primarily by the ovaries, it is a natural hormone that develops female characteristics such as voice, skin texture, genital tracts and the female psyche itself. Women tend to lose all those when they stop producing estrogen."

At this point, most women experience menopausal symptoms such as hot flashes, night sweats, insomnia, irritation, anxiety, forgetfulness, depression and lack of concentration. There are other signs too. All of a sudden women seem to develop high cholesterol, high blood pressure or osteoporosis. A couple of decades ago, women suffered these symptoms in silence and accepted them as part of life or the ageing process. "It did not matter those days when life expectancy was around 55 years for a woman. Life expectancy for an average Sri Lankan woman now is 74 years," Prof. Seneviratne says.

"With one third of her life ahead of her, a woman is capable of doing many things. By taking HRT, she can be assured of a better quality of life," says Dr. Ranjith Almeida (gynaecologist) who practises at Asha Central Hospital and Castle Street Hospital.

"Modern day women need not resign themselves to this when there is a remedy available."

Menopausal symptoms cause much agony. Even with the A.C. on, women break out in a cold sweat, experience hot flushes and suffer from various vaginal infections. Many also suffer from back pain. From a simple fall or the smallest impact, women are known to break bones.

Emotional health is also affected. Acute mood swings, lack of energy, fatigue and depression are common. Metabolism changes and slows down. They can just look at food and put on weight and are also more prone to heart attacks.

"People on insulin cannot do without it. Similarly, the lack of estrogen can cause much distress and therefore needs to be replaced," explains Dr. Seneviratne. Today, gynaecologists in Sri Lanka recommend Hormone Replacement Therapy (HRT) for women suffering from severe symptoms of menopause. "They can benefit from the replacement of these female hormones."

"The obvious repercussions of not taking estrogen on a short-term basis are hot flushes, profuse sweating and an effect on brain functions (depression, anxiety, etc.) which can be very distressing, although they may not apply to all. On a long term basis, bones lose their calcium and no amount of calcium intake can replace the loss. This may lead to hip fracture, bent spine (hunch), spine fracture, etc. Further, all pelvic organs and support ligaments are dependent on estrogen for integrity and activity. These include the female genital tract and urinary system. Women with cholesterol are also known to benefit from estrogen," Dr. Seneviratne continues.

What are the benefits? Estrogen has been proved to be very effective in treating menopausal symptoms. It can certainly reduce those immediate symptoms like hot flushes, sleeplessness and vaginal dryness. It may improve mood and psychological wellbeing in women, their behaviour and sleep patterns. There are other reports stating that estrogen prevents memory loss, delays the onset of Alzheimer's disease, prevents colon and bowel cancer and improves urinary incontinence.

HRT involves treatment with estrogen alone or in combination with progestin. This compensates for the decrease in natural hormones that occurs at menopause. Women who have had their uterus removed are given estrogen alone, whereas women with a uterus take a combination of estrogen plus progestin.

What of the side-effects? There are thousands of web sites that highlight the adverse effects - breast cancer, cardiovascular disease, uterine cancer, etc. These results indicate that the risks of long-term estrogen with progestin outweigh the benefits.

HRT sounds like a risky proposition. How safe is it? Most gynaecologists think it is a necessary solution to evade the agonising effects of menopause.

Explaining that some, possibly because of a healthy lifestyle 'age gracefully' while others have a traumatic time, Dr. Nalini Prasad, gynaecologist of Apollo Hospital says, "HRT should be tailormade for women after balancing the risks and benefits. The risk factor varies from woman to woman depending on their genetics, the environment they were brought up in, their lifestyle and family history of health problems and therefore cannot be generalised."

Patients are counselled and advised of the pros and cons of taking HRT and are encouraged to take the treatment with a specialist's approval and under medical supervision.

"Cancer can occur in women who are on HRT. But the incident is only slightly higher than three in a thousand. We cannot predict it. You can still get cancer even if you do not take HRT. You may die of high blood pressure or stroke, you may fall and fracture a bone caused by low estrogen levels. We know for sure that women who take estrogen, do not get infarcts," says another gynaecologist.

Most drugs have adverse effects, the gynaecologists say. Even the common aspirin is known to cause stomach ulcers. The risk of taking HRT however, can be overcome by regular routine breast examinations or pap smears, ultra sounds and endometrial biopsy (DNC) once every two years, thereby detecting any cancer in its earliest stage and commencing treatment that in most cases can cure a person.
(To be continued)

On the floor, on a trolley
Vijaya Jayasuriya relates his experiences as a patient of the Cardiology Unit of the National Hospital
It was with a sense of natural apprehension that I stepped into the country's leading cardiology unit attached to the National Hospital (CU) as a heart patient for a test called Coronary Angiogram (CA).

All distinctions of social hierarchy blurred into a very facile nonentity as I had to sleep all three days without a bed, two days on the ward floor desperately trying to cushion the knocks of my ageing bones on concrete with a mat provided to all and sundry by a seemingly considerate yet voluble male attendant. The day spent on a trolley was the biggest trauma, for, following the CA - just out of the theatre - you were supposed to stay put without even turning your leg lest the slit made on your crotch to insert a tube into an artery might open up by the slightest movement or jerk making you bleed profusely.

Lying on your back on the metal surface of a trolley for nearly 10 hours was agony for me. Specially since all eight other people, some thirty or thirty-five year olds among them taken for the same test that day being lucky enough to get a bed. However, I tremendously enjoyed the camaraderie among the patients with social ranks merging into nothingness, despite all difficulties.

Having declared that I would require by-pass surgery, I was sent a day after the CA to see a surgeon at the OPD. Four of us jostled into an ambulance by a youthful yet arrogant attendant, we arrived there to wait with a milling crowd under a low asbestos roof heated like an oven - ideal conditions for a weak heart patient like me - only to find that the surgeon had not turned up and only his assistants were there which meant that you would be put to a ward there until the day the big man comes.

After consulting the doctor, we sat on the now empty benches as the crowd diminished with the evening and were waiting for our conveyance when somebody arrived to call it a day ordering us out and locking up the place. Now, minus even a bench to slump down on and dead beat too, we, the four victims of licensed lethargy hung on, resting our haunches on the brick paving of a building for nearly one hour waiting to be taken back to our ward.

The nurses at the CU however were doing a thorough job of work to treat and keep the patients in comfort as far as possible and this much is commendable apart from the young set of doctors attached to the wards who proved to be kind-hearted gentlemen so far as their duty was concerned.

On the operating table, a young doctor performed the CA on me puncturing an artery on my crotch. They applied a liquid profusely over that area and then started inserting the tube. Immediately I could feel the pain. No one asked me if I could feel or not, as the private dentist would ask you about the injection before he pulls out your tooth. I jerked my leg in pain only to be met with a stern warning of more pain if repeated. When later I asked a partner in adversity he told me surprisingly that he had not felt anything at all, and it was a different surgeon who had done his CA. Is there an individual factor involved in whether you are severely dealt with or not, on the operating table?

In a cubicle outside the theatre it is a veritable pantomime enacted by some attendants (or are they nurses?) to plug the flow of blood from my injury. They dabbed it with a thick wad of wool and kept pressing upon it with both hands. Using their full body weight, they removed the wad and if it still flowed repeated the same procedure several times taking about 20 minutes. My problem was that I had a slight swelling on probably a gland on my crotch which at least the doctor should have noticed before puncturing the place. So the pain was excruciating when the young fellow was pressing on the very place with his full body weight and I had no choice but to undergo the ordeal in silence.

But these drawbacks apart, the wards of the unit prove to be a place akin to heaven except for a few inevitable shortcomings. I saw even in small hours of the night female nurses come running to patients who begin to shout in pain and provide them with whatever was necessary. Even the doctors made several rounds in the dead of night to attend to a patient who had taken a bad turn.

The meals were tolerable with two or three curries while the standards of sanitation was kept at a fairly high level - the ward floor was regularly mopped and it was the fault of patients themselves that often created problems - for instance, clogging the sinks with food particles in spite of having a bin.

I believe that the CU is run according to some principles to do with the actual conditions governing a heart patient who deserves to be dealt with tenderly as he is more prone to anxiety and tension than an ordinary one. The staff therefore appears to have been well-trained accordingly, not to cause unnecessary mental stress for them. There are however two issues requiring discreet handling; firstly, getting the patients to sign the document undertaking to bear the risk involved in CA is only kept open to those who can read English well, lest only plebeians will try to make a scene if risks are made clear to them. The second point that should improve is the obvious favours rendered on grounds of attachment which is anyway inevitable and therefore those at the receiving end should not try to make a show of it. If these aspects are improved, the Cardiology Unit would be rated much better than any of its much - vaunted private counterparts.

Peace and quiet for the hopeless
The only hospice we have in Sri Lanka, Shantha Sevana, situated near the Cancer Hospital in Maharagama, is like an oasis of tranquillity for suffering people. Those who have visited the Cancer Hospital will best appreciate the contrast it offers. Here is a place that is pleasant, clean and airy, with a limited number of beds and nurses and attendants who provide the kind of care those awaiting death need.

There are two wards, each having 16 beds - the one for males is downstairs and the female ward is upstairs. There are also two rooms to accommodate patients who come with a carer to stay with them. The kitchen is clean and shining. The toilets are well kept. The bed 1inen looked fresh and clean and the patients appeared well cared for. The nursing Sister who showed us round, Sister Pannala, seemed dedicated to her work. With long service in government hospitals behind her, and a stint at the Royal Marsden Hospital in England, she had taken early retirement and then opted to serve here. While the nurses I saw were on the elderly side, the attendants, both male and female, were youthful. There is also a team of volunteers who visit the patients on a regular basis, but we did not meet any on that particular day.

I spoke to a patient who was sitting on his bed with his legs dangling down. He was Mr. Appuhamy who appeared to have cancer of the mouth, for he could only speak from one corner of it. He said he had been in the hospice for 1 l/2 years, after a long stay at the Cancer Hospital, and he was fortunate to be able to end his days in a place like this. He had no family, friends nor relatives to visit him, yet was cheerful and uncomplaining.

Moving on, I came to the bed of a man with a big, greying moustache and a ready smile and only one leg. There were crutches leaning on the wall beside his bed. He was Mr. Subramaniam from Wattala and he had children who often visited him. He told us that he had been promised an artificial limb by some society at the Gangaramaya and he was awaiting that. I winced when he volunteered to take off the bandage round his stump, but he cheerfully undid it and told us how, after the original amputation, a further portion had to be cut off. It has now healed completely and he looks forward to getting the new limb and learning to walk with it. He even talked of going home, but I learned privately from the Sister that it was more likely he would remain at Shantha Sevana because, although he didn't seem to be aware of it, he was a terminally ill patient, like all the others in the hospice.

In the female ward upstairs, we were drawn to the bedside of a patient who had bunches of gaily-coloured artificial flowers on her bed. She, Karunawathie, spends most of her time making these flowers and sells them to visitors. It was something she had learned while in domestic service. Karunawathie had suffered from a brain tumour and was blind when she was admitted to the Cancer Hospital. After surgery to remove the tumour, she got partial sight - just enough to enable her to engage herself in this therapeutic occupation which she enjoys and which also brings her a modest income. She told us that one of the volunteers buys the required materials for her. Everyone of us was glad to buy a bunch of Karunawathie's pretty flowers priced at Rs. 10 per flower.

Seelawathie, paralysed on one side, sits up in bed making drawings, using pastels and this is obviously occupational therapy for her. Sometimes, the nurses pin up her work on the wall beside her and this makes her happy. Several of the patients were out in the hall, listening to a bana sermon being given by a monk, preceding a dhana that a benefactor was giving the patients that day. That must be how we missed meeting Malkanthi. This lady has lost her husband and only child and now, stricken with cancer, she bravely carries on and finds some meaning to her days in teaching English to the young nurse-aides.

We met only one patient who was in tears. This lady had been brought to Shantha Sevana from Trincomalee only the day before and must have felt strange and lonely in the unfamiliar surroundings because she spoke only Tamil and therefore couldn't communicate by word with nurses or fellow-patients. She cheered up considerably when one of our group who knew Tamil, spent a little time chatting with her and listening to her.

The three young nurse-aides have one off day a week and 21 days privilege leave for a year. I asked them whether they didn't find it depressing to care for terminally ill patients, some of whom were in constant pain. They smiled and said "No" and one of them, Chandima Ratnayake, spoke for all three when she said in Sinhala, "This is merit-earning work."

In a passage, I saw a large board on which the meals donated for each day are written down, along with the names of the donors. I noticed that breakfast for on that particular day had been 'donated by Miss Chandima Ratnayake in loving memory of her father.' I was touched that this young girl had been moved to give Rs. 350 out of her hard-earned money (we later enquired from the office about the amount required for different meals). We were also told that two items often in short supply are milk powder and sugar and that gifts of these are always welcome.

Only the terminally ill are admitted to Shantha Sevana, so a letter from a consultant recommending admission is essential. It's absolutely free of charge. If well-to-do patients come in, they may make a voluntary donation if they wish, but they are not asked to make any payment for services rendered. No treatment is given at the hospice, for that part is over for those who come here. A doctor visits the patients regularly and pain-killers are given to those who need them and they are kept as comfortable as possible.

We were surprised that there were a few vacant beds. Vacancies do occur, of course, as and when terminally ill patients die, but I would have expected there to be a long waiting list and that vacant beds would be immediately snapped up. I asked Ms. Perin Captain about this and she too was dismayed that this didn't always happen and wondered herself why it was so. This hospice was Perin's dream which the Captain family helped her to fulfil. I attended its formal opening by Prime Minister Sirimavo Bandaranaike in 1996 and she said it was a place that would meet a felt need.

Shantha Sevana gives hope to people who might feel hopeless after the long and painful process of being treated for cancer. I don't mean the hope of recovery, but hope of some quality of life during the months or years that are left to them. I noticed pictures on the walls, television in the ward, fish tanks, a well-tended garden with stone benches. To destitute and lonely people, particularly, a haven such as this where they meet with kindness and tender care and can die in clean and pleasant surroundings, with decency and dignity, must make a world of difference.
- Anne Abayasekara

Symposium on Asthma
A Symposium on Varied Aspects of Bronchial Asthma will be held on Sunday, November 17 at the Colombo Hilton. The symposium has been organised by the Respiratory Disease Study Group. 22 Specialist speakers will make presentations. Doctors are requested to telephone 695418, 05522483 for further particulars.

The presentations will be as follows: Current scenario in asthma - Dr. Kirthi Gunasekera, Inflammatory mechanisms and airway remodelling - Dr. Manela Joseph, Natural history and clinical spectrum - Dr. A. T. Munasinghe, Allergens, immunology and immunotherapy - Dr. Anura Weerasinghe, Recent developments in occupational asthma - Ms. K. N. Lankathilaka, Clinical studies in asthma - Dr. Rajitha Wickremasinghe, Diagnostic difficulties in asthma - Dr. J.H.L Cooray, Acute, severe asthma - Dr. Shyam Fernando, Ventilatory strategies in asthma - Dr. Vajira Tennekoon, Conventional pharmacotherapy - Dr. Bandu Gunasena and Inhaled cortcosteroids - Dr. B. J. C. Perera.


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