ISSN: 1391 - 0531
Sunday, August 19, 2007
Vol. 42 - No 12
MediScene  

Have I got Cervical Cancer?

A good prevention programme including the use of home remedies to detect it, could help keep this second most common cancer in Sri Lanka among women at bay.

By Kumudini Hettiarachchi

The picture on the screen was of an elephant - a huge one at that, at the presentation at the Family Health Bureau auditorium.
That is how big the issue is of the subject matter of the presentation. Cervical cancer is an elephantine problem all over the world. The statistics are shocking – 480,000 new cases are identified each year – with 80% of new cases occurring in the developing world.

Screening for Cervical Cancer

Around 230,000 women die of cervical cancer each year. In Sri Lanka, there are around 1,100 new cervical cancer cases per year and this is the second largest killer among cancers that affect women, the first being breast cancer.

What is the answer? The obvious one is early diagnosis through a pap smear, and then treatment.

But Prof. Paul D. Blumenthal of the Johns Hopkins University had a different view on the development and adoption of appropriate strategies for cervical cancer prevention in low-income settings, the important word being appropriate.

Take some of the Sri Lankan settings - yes, we have a commendably low infant and maternal mortality rate and also a health system that reaches out through a network of family health workers to every village.

However, can all women in the crisis age-group get themselves tested through pap smears, for which they have to come to a clinic? Even if they do get themselves tested and are found to be positive, how many will come for follow-up treatment crucial to keep this killer at bay?

With families to look after, water to carry, fields to work, hardly a bus plying through villages in the remoter areas, some women may come for follow-up treatment when it is too late. Their solution could lie in a simple test that can be carried out in the homes of the women themselves by the family health worker, using what every kitchen has.

What is available in Sri Lanka?

Cervical screening laboratories have also been established in many districts and colposcopic facilities are available in most provinces, she said.

"Vinegar," explains Prof. Blumenthal stressing that cervical cancer is preventable when pre-cursor lesions are detected and treated before they develop into cancer. Pointing out a unique public health opportunity, he says that what is needed is just two weeks of training for the family health worker.

"Visual inspection with acetic acid (VIA) involves only swabbing the cervix with a 3-5% acetic acid (vinegar) solution before examination using a strong light such as a good torch," says Prof. Blumenthal adding that sensitivity to VIA is equivalent to or better than that of cytologic examination. The vinegar would turn abnormal cells white indicating malignancy and the health worker only needs her eyes to spot it.
Another simple testing method could be the use of Lugol's iodine which when applied to the cervix would stain brown or black on areas that contain glycogen. "The lesions don't contain glycogen and would appear as well-defined thick mustard or saffron-coloured areas," Prof. Blumenthal said.

With women in remote areas, the barrier is follow-up care. They have to get a pap smear done, then a colposcopic examination or biopsy and then come again for treatment, he said adding that along with the VIA or Lugol's iodine test, the health worker could treat the woman immediately if she is armed with the cryo-gun to administer cryotherapy. MediScene learns that cryotherapy is the application of extreme cold to destroy diseased tissue.

Prof. Blumenthal details a good prevention programme as being able to reach a significant percentage of at-risk women; including effective testing; treating and managing women who test positive, ensuring effective follow-up and monitoring and evaluation.

Cervical cytology has limitations because for that not only laboratories but also cyto-technicians are needed, according to him. "VIA, however, is technology that works in unsophisticated surroundings while also being inexpensive. All test requirements are materials available locally and the tests can be performed by non-physicians."

Which one is cheaper? Which one gives immediate results? VIA and cryotherapy seem to be the obvious answers. "Once covered, the women don't need to come to the clinic for five years. One screening reduces death by 30%," he says, whereas if a woman is tested positive in a pap smear but doesn't come back it is a missed opportunity to save a life. The “good” is not the enemy of the “best”, he says. The best is the pap smear but what if you can't do it? Then acetic acid or iodine will be as good, is the important message from Prof. Blumenthal.

What is cervical cancer?
Cervical cancer, the second most common cancer afflicting women (in Sri Lanka) occurs when abnormal cells in a woman's cervix -- the lowest part or the neck of the uterus or womb -- divide and grow out of control. Most scientific studies point to the human papillomavirus (HPV) infection as a necessary pre-requisite for the development of cervical cancer.
Symptoms

Vaginal bleeding could indicate cervical cancer but symptoms may be absent until the cancer is in an advanced stage. Contact bleeding or rarely a vaginal mass may indicate the presence of malignancy. Other signs could be moderate pain during sexual intercourse and vaginal discharge.

The symptoms of advanced cervical cancer may include loss of appetite, weight loss, fatigue, pelvic pain, back pain, leg pain, single swollen leg, heavy bleeding from the vagina, leaking of urine or faeces from the vagina and bone fractures.

The most important risk factor in the development of cervical cancer is infection with a high-risk strain of HPV. Even though HPV is an important risk factor for cervical cancer, most women with this infection do not get cervical cancer and doctors believe other risk factors must come into play for this cancer to develop. Having unprotected sex, especially at a young age, makes HPV infection more likely. Women who have many sexual partners (or who have sex with men who have had many partners) have a greater chance of getting HPV.

Tests

While the pap smear is an effective screening test, confirmation of the diagnosis of cervical cancer or pre-cancer requires a biopsy of the cervix.

Pap test is the collection of cells from the cervix for examination under a microscope, to detect changes that may be cancer or may lead to cancer, and can also show non-cancerous conditions, such as infection or inflammation.

 
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Copyright 2007 Wijeya Newspapers Ltd.Colombo. Sri Lanka.